Assessment of cumulative evidence on genetic associations: interim guidelines.
نویسندگان
چکیده
Established guidelines for causal inference in epidemiological studies may be inappropriate for genetic associations. A consensus process was used to develop guidance criteria for assessing cumulative epidemiologic evidence in genetic associations. A proposed semi-quantitative index assigns three levels for the amount of evidence, extent of replication, and protection from bias, and also generates a composite assessment of 'strong', 'moderate' or 'weak' epidemiological credibility. In addition, we discuss how additional input and guidance can be derived from biological data. Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors.
منابع مشابه
GENETIC EPIDEMIOLOGY Assessment of cumulative evidence on genetic associations: interim guidelines
Established guidelines for causal inference in epidemiological studies may be inappropriate for genetic associations. A consensus process was used to develop guidance criteria for assessing cumulative epidemiologic evidence in genetic associations. A proposed semiquantitative index assigns three levels for the amount of evidence, extent of replication, and protection from bias, and also generat...
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عنوان ژورنال:
- International journal of epidemiology
دوره 37 1 شماره
صفحات -
تاریخ انتشار 2008